NK cells are large granular lymphocytes which are identified by their lack of T cell receptors, and their surface expression of CD16 and CD56 receptors. NK cells are mainly known for their ability to kill tumors and provide crucial cytokines to activate adaptive immunity. NK cells play a major role in the host-rejection of both tumors and virally infected cells.
OUR PREVIOUS STUDIES
ADVANCING RESEARCH USING HUMANIZED MICE
Dr. Jewett’s patented technology takes normal mice, and turns them into “humanized mice” that pump human blood, which makes them over 90% more similar to humans. This results in pre-clinical trials that are more successful when moving from animal models to human trials.
MAJOR DEFECTS IN NK FUNCTION IN CANCER PATIENTS
FOR A FULL LIST OF DR. JEWETT'S 119+ NK CELL PUBLICATIONS -https://loop.frontiersin.org/people/116826/overview
Multiple Defects of Natural Killer Cells in Cancer Patients: Anarchy, Dysregulated Systemic Immunity, and Immunosuppression in Metastatic Cancer
http://dl.begellhouse.com/journals/2ff21abf44b19838,62b8a7004695c197,3d9b031b6a8cfac3.html
Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells.
Probiotic-Treated Super-Charged NK Cells Efficiently Clear Poorly Differentiated Pancreatic Tumors in Hu-BLT Mice
Molecular heterogeneity in breast carcinoma cells with increased invasive capacities
Super-charged NK cells in combination with tumor vaccine inhibit growth and progression of Melanoma tumors in vivo in humanized BLT mice; effect on tumor differentiation and response to chemotherapeutic drugs.
Super-charged NK cells inhibit growth and progression of stem-like/poorly differentiated oral tumors in vivo in humanized BLT mice; effect on tumor differentiation and response to chemotherapeutic drugs.
https://www.tandfonline.com/doi/full/10.1080/2162402X.2018.1426518
Cell Budding from Normal Appearing Epithelia: A Predictor of Colorectal Cancer Metastasis?
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